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Anti-Peptide ADG T cell receptor (5CC7), pCDTCR1 (TCR-YC0876)

For 2B4 and 5cc7, TCR bound the pMHC of interest with affinities ranging from KD of 1 μM (over 10-fold better than MCC) to those with binding only barely detectable at 100 μM TCR.

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Details

  • Target
  • Peptide ADG
  • Epitope
  • ADGLAYFRSSFKGG
  • Format
  • Non-Modified TCR
  • Allele
  • H2-IEk
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • 5CC7
  • Host Species
  • Mouse

Target

  • Introduction
  • T cells are central to many aspects of adaptive immunity. Each mature T cell expresses a unique αβ T cell receptor (TCR) that has been selected for its ability to bind to peptides presented by major histocompatibility complex (MHC) molecules. Unlike antibodies, TCRs generally have low affinity for ligands (KD ~ 1-100 μM), which has been speculated to facilitate rapid scanning of peptide-MHC (pMHC).

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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