CellRapeutics™ CD56⁺ NK Cells from Rheumatoid Arthritis Donor (XS-0426-XU298)

Name: CellRapeutics™ CD56+ NK Cells from Rheumatoid Arthritis Donor
SKU: XS-0426-XU298
Rating: 5 (1 reviews)

Online Inquiry Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

These CD56⁺ NK cells are purified from the PBMCs of donors with Rheumatoid Arthritis. In the context of chronic synovitis, these cells are often found in a hyper-activated state, contributing to bone erosion through the production of RANKL and inflammatory cytokines. This product is specifically designed for analyzing the migration of NK cells into the synovial space and their interactions with rheumatoid arthritis synovial fibroblasts.

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Donor Information

Product Name
CellRapeutics™ CD56⁺ NK Cells from Rheumatoid Arthritis Donor

Cat. No.
XS-0426-XU298

Donor Age
Middle-Aged

Donor Health
NK cells reflect a systemic musculoskeletal autoimmune environment. They exhibit a pro-inflammatory secretory phenotype and are often pre-activated by the cytokine-rich milieu characteristic of chronic synovial inflammation.

Ethnicity
Diverse backgrounds available, predominantly Caucasian and East Asian cohorts.

Anticoagulant
Acid Citrate Dextrose or Heparin, optimized to mitigate the impact of rheumatoid factors and circulating immune complexes on NK cell activation and viability.

Additional Donor Information
Each lot features CD56⁺ NK cells from donors with RA. Profiles include RF/CCP antibody titers and DAS28 scores, supporting research into the NK cell role in synovial inflammation and bone erosion.

Clinical Profile
Sero-status, joint involvement count, DAS28 score, and history of methotrexate or TNF inhibitors.

Additional Information

Medication History
Available upon request. Includes history of DMARDs and biological therapies targeting TNF or IL-6 that may alter NK cell activation thresholds.

Formulation
Cryopreserved in specialized freezing medium

Cell Purity
>90%

Cell Viability
>90%

Mycoplasma Testing
Negative

Sterility Testing
Negative

Genetic Stability Testing
The donor cells maintain their native genetic profile, exhibiting no karyotypic abnormalities or chromosomal instabilities typically associated with prolonged ex vivo expansion.

Application
Drug Discovery, Immuno-oncology Research

Research Use Only
RUO

Quality Control
Each product batch undergoes rigorous testing for purity, viability, and microbial contamination.

Storage
Maintain long-term storage in liquid nitrogen vapor phase (below -150°C), avoid temperature fluctuations above -135°C to preserve NK cell lytic activity.

Shiping
Dry Ice

Handling Notes
Perform rapid thawing at 37°C and implement slow, dropwise dilution with pre-warmed media to minimize osmotic stress and ensure optimal cell recovery.

Warnings
Treat as potentially biohazardous human-derived material and handle strictly under BSL-2 guidelines using appropriate personal protective equipment.

Size
5E6 cells/vial, 1E7 cells/vial

Keywords
CellRapeutics™ CD56⁺ NK Cells from Rheumatoid Arthritis Donor, CD56⁺ NK Cells, Rheumatoid Arthritis

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.