CellRapeutics™ Leukopak from Systemic Lupus Erythematosus Donor (XS-0426-XU249)

Name: CellRapeutics™ Leukopak from Systemic Lupus Erythematosus Donor
SKU: XS-0426-XU249
Rating: 5 (1 reviews)

Online Inquiry Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This Leukopak is procured from donors meeting the criteria for Systemic Lupus Erythematosus, offering a high-density population of cells involved in multi-organ autoimmunity. The leucocyte profile is characterized by a prominent Type I Interferon signature, aberrant B-cell maturation pathways, and defective apoptotic clearance mechanisms. It is a vital substrate for large-scale analysis of antinuclear antibody production and the study of the pathogenic crosstalk between plasmacytoid dendritic cells and autoreactive B cells.

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Donor Information

Product Name
CellRapeutics™ Leukopak from Systemic Lupus Erythematosus Donor

Cat. No.
XS-0426-XU249

Donor Age
Young Adult

Donor Health
Donors exhibit multisystemic autoimmunity. The cell population is defined by a loss of B-cell tolerance, expanded autoreactive T-cell subsets, and signatures of profound systemic immune activation.

Ethnicity
Predominantly African American, Hispanic, and Asian backgrounds.

Anticoagulant
Acid Citrate Dextrose, strictly controlled to minimize DNA release and prevent pre-analytical activation of pDCs and B cells.

Additional Donor Information
Each lot features a Leukopak from donors meeting ACR criteria for SLE. Profiles include ANA titers and disease activity scores, enabling large-scale analysis of interferon-signature genes and B-cell abnormalities.

Clinical Profile
Disease activity markers, major organ involvement, and current immunosuppressive regimen.

Additional Information

Medication History
Available upon request. Records of hydroxychloroquine, corticosteroids, and systemic immunosuppressants or biologics.

Formulation
Cryopreserved or Fresh options available.

Cell Purity
>90%

Cell Viability
>90%

Mycoplasma Testing
Negative

Sterility Testing
Negative

Genetic Stability Testing
The donor cells maintain their native genetic profile, exhibiting no karyotypic abnormalities or chromosomal instabilities typically associated with prolonged ex vivo expansion.

Application
Drug Discovery, Immuno-oncology Research

Research Use Only
RUO

Quality Control
Each product batch is strictly validated for high cellular viability, specific immune cell counts, and pathogen-free safety, ensuring consistent clinical phenotypes and ethical compliance for advanced immunological research.

Storage
Store fresh Leukopaks at 2°C to 8°C for immediate use, cryopreserved samples must be kept in liquid nitrogen vapor phase below -150°C.

Shiping
Dry Ice

Handling Notes
Process fresh cells within 48 hours or perform rapid thawing of cryovials in a 37°C water bath followed by gradual dilution to maximize recovery.

Warnings
Treat as potentially biohazardous human-derived material and handle strictly under BSL-2 guidelines using appropriate personal protective equipment.

Size
Full Bag, Half Bag

Keywords
CellRapeutics™ Leukopak from Systemic Lupus Erythematosus Donor, Leukopak, Systemic Lupus Erythematosus

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.