FITC-labeled Human Glypican3 CAR Detection Reagent, Fc Tag (CARD-LX006)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Evaluating CAR expression is an essential step in the production of CAR-T cells. Creative biolabs provides several detection reagents which are uniquely suitable for evaluation of CAR expression. FITC-labeled Human Glypican3 CAR Detection Reagent, Fc Tag is a special detection reagent which carries a human IgG1 Fc tag at the C-terminus, and is used to detect human Glypican3 CAR related to the study of Hepatocellular carcinoma.

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Specifications

Target
Glypican3

Application
ELISA, FC

Purity
>90%

Endotoxin Level
Less than 1.0 EU per μg by the LAL method.

Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please protect from light and avoid repeated freeze-thaw cycles.

Application Notes
The optimal working dilutions should be determined by the end user.

Diseases
Hepatocellular carcinoma

Molecular Characterization
It contains AA Gln 25 - His 559 (Accession # P51654-1). It is the FITC labeled form of Human Glypican 3, Fc Tag.

Conjugation
FITC

Tag
Fc Tag

Size
0.2 mg

Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Expression
Human HEK293 cells

Host Species
Human

Species Reactivity
Human

Form
Lyophilized

Images
Figure 1 Structure

Target

Target Introduction
Glypican-3 (GPC3) is also known as Intestinal protein OCI-5, GTR2-2, MXR7, which belongs to the glypican family. Glypican 3 / GPC-3 is highly expressed in lung, liver and kidney. Glypican-3 inhibits the dipeptidyl peptidase activity of DPP4. Glypican-3 may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs, and also may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function.

Target Alternative Names
glypican 3

Entrez Gene ID
2719

UniProt ID
P51654-1

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.