VivoCAR™ Anti-CD117 (20376) h(CD28-41BB-CD3z) CAR saRNA (XS-0326-XU96)

Name: VivoCAR™ Anti-CD117 (20376) h(CD28-41BB-CD3z) CAR saRNA
SKU: XS-0326-XU96
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-CD117 (20376) h(CD28-41BB-CD3z) CAR saRNA employs a high-efficiency saRNA backbone to deliver the 20376 clone. For in vivo therapy, this clone is distinguished by its precise binding kinetics to CD117, optimized for targeting leukemic cells with high target density. By utilizing the biological magnification effect of saRNA, the product achieves sustained CAR expression following in situ reprogramming, providing a potent and dose-sparing strategy for depleting malignant clones in the bone marrow before stem cell transplantation.

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CAR Information

Target
CD117

Target Species
Human

Antibody Clone
20376

scFv Host Species
Mouse

Receptor Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation CD28-41BB-CD3ζ architecture employs a sequential costimulatory strategy, where the CD28 module drives rapid initial activation and metabolic reprogramming, while the 4-1BB component sustains long-term cellular viability and mitigates exhaustion. This tandem design, anchored by the CD3ζ signaling chain, synergistically amplifies downstream signal transduction, resulting in a balanced T-cell phenotype with robust effector capacity and prolonged durability. The integrated signaling cascade thus optimizes both kinetic expansion and persistence, enhancing antitumor efficacy.

CAR saRNA Properties

Structure
Linear

Cap
Cap 1

PolyA
Segmented PolyA

Product Type
CAR IVT saRNA

Concentration
Lot specific

Buffer
1 mM Sodium Citrate, pH 6.4 (or specialized RNA storage buffer, RNase-free).

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

saRNA Quality Control

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

Target Information

Full Name
Cluster of Differentiation 117

Alternative Names
C-Kit; KIT; MASTC; PBT; SCFR

Introduction
CD117 is a cytokine receptor tyrosine kinase expressed on hematopoietic stem cells and certain cancers. It plays a critical role in cell survival, proliferation, and differentiation, and is frequently mutated or overexpressed in leukemia.

Targeting Diseases
Acute Myeloid Leukemia (AML), Gastrointestinal Stromal Tumor (GIST), Mastocytosis

UniProt ID
P10721

Gene ID
3815

Case Studies

Customer Reviews and Q&As

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.