VivoCAR™ Anti-CD79B (MA79b) h(CD28-41BB-CD3z) CAR saRNA (XS-0326-XU76)

Name: VivoCAR™ Anti-CD79B (MA79b) h(CD28-41BB-CD3z) CAR saRNA
SKU: XS-0326-XU76
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-CD79B (MA79b) h(CD28-41BB-CD3z) CAR saRNA leverages the saRNA platform to express the MA79b clone. In vivo, this clone is highly valued for its proven clinical efficacy in targeting the CD79B component of the B-cell receptor. The biological magnification of saRNA ensures that a minimal systemic dose leads to robust CAR expression, enabling T cells to achieve the sensitivity required for in situ B-cell depletion in patients with aggressive or relapsed B-cell lymphomas.

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CAR Information

Target
CD79B

Target Species
Human

Antibody Clone
MA79b

scFv Host Species
Mouse

Receptor Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation CD28-41BB-CD3ζ architecture employs a sequential costimulatory strategy, where the CD28 module drives rapid initial activation and metabolic reprogramming, while the 4-1BB component sustains long-term cellular viability and mitigates exhaustion. This tandem design, anchored by the CD3ζ signaling chain, synergistically amplifies downstream signal transduction, resulting in a balanced T-cell phenotype with robust effector capacity and prolonged durability. The integrated signaling cascade thus optimizes both kinetic expansion and persistence, enhancing antitumor efficacy.

CAR saRNA Properties

Structure
Linear

Cap
Cap 1

PolyA
Segmented PolyA

Product Type
CAR IVT saRNA

Concentration
Lot specific

Buffer
1 mM Sodium Citrate, pH 6.4 (or specialized RNA storage buffer, RNase-free).

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

saRNA Quality Control

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

Target Information

Full Name
Cluster of Differentiation 79b

Alternative Names
AGM6; B29; IGB; Igbeta

Introduction
CD79B is the signal-transducing partner of CD79A in the B-cell receptor complex. It is a critical marker for B-lineage cells and is frequently targeted in lymphoma therapy.

Targeting Diseases
B-cell Acute Lymphoblastic Leukemia (B-ALL), Non-Hodgkin Lymphoma (NHL), Chronic Lymphocytic Leukemia (CLL)

UniProt ID
P40259

Gene ID
974

Case Studies

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.