Peptide Microarray Technology for Vaccine Design
The extreme complexity of biological systems places high demands on the tools to study this aspect. The emergence of microarray has greatly accelerated the progress of global biological research. Creative Biolabs has been at the forefront of the vaccine industry for more than a decade for that we are constantly committed to building the most professional research team, thirstily absorbing the most cutting-edge, most efficient technology and combining practical experience with the technology to turn it into a more valuable tool. We are not the inventor of peptide microarray technology, but we have extended its value to the extreme, so we are confident that in the aid of such a powerful tool, we can perfectly meet any of your requirements.
Peptide Microarray
The development of Microarrays offers the possibility of high-throughput parallel screening. From the specific application for finding molecular hits to the current fine-grained dissection of disease biology, a large number of original and efficient microarray platforms have been developed, greatly increasing the productivity of scientific research. Emerging synthesis, immobilization technology, and peptide library design have also accelerated the boom in this field. Microarray presents molecules in a two-dimensional plane in the form of a grid. Each molecule occupies a predetermined position in the grid, called a spot, size of which is in the micrometer range and the spot is also the identity of the molecule. The benefit of this analytical approach is that the reactions at each point are independent and it can reduce the amount of analytes and samples required for the given reaction. As surface chemistries and immobilization techniques advance, molecules that can be coated into microarrays now encompass chemicals, tissues, proteins, nucleic acids, and even living cells. Besides, the methods that detect the binding on arrays have also evolved from the initial fluorescent labeling to label-free optical impedance detection, mass spectrometry-based techniques and surface plasmon resonance. Peptide microarrays are a relatively widely used aspect of small molecule microarrays, which show great power in drug discovery, biomarker discovery, and disease detection. Applying it to epitope mapping, tumor neoantigen discovery, etc. immensely promoted the development of related vaccines.
Fig.1 Strategies for the fabrication of peptide and small molecule microarrays. (Foong YM and Fu J, 2012)
Features of Peptide Microarray
- Simple synthesis and low cost
- Wide range of applications
- Stable shelf life
- High batch-to-batch production capacity
Custom Peptide Microarray
As mentioned above, peptide microarrays are ideal high-throughput tools for analyzing antigen-antibody interactions, performing epitope mapping, and cancer neoepitope discovery. Maybe the application of this technology is so rich that you are dazzled and can't catch the focus. Don't worry, our customized peptide microarray service will precisely design the right experimental solution for your needs, and will be executed in strict accordance with the program and related standards to ensure the validity and reliability of the results.
Peptide microarray technology has now become a routine means of biological research, and each company has modified and launched the basic technology, but it is worth noting that although this technology has mushroomed rapidly, the quality of which is uneven among firms. As a powerful tool for vaccine research and development, how to combine technology and corresponding immunology knowledge and how to make them fit well, how to rationally optimize technology based on the actual experience of vaccine research are the focuses of continuing to develop and utilize peptide microarray technology, which is also a Gordian knot.
Compared with other peptide microarray technology, we use Fmoc method to perform peptide synthesis directly on the chip, which is fast and accurate. For the need for epitope mapping, we can design the appropriate peptide length according to the specific needs of customers and produce the highest resolution overlapping peptide library. For the discovery of cancer neoepitope, we combine SepaMatrix's powerful epitope prediction capabilities with the established neoepitope library to successfully achieve your goals in this area, and our cancer vaccine service can also provide you with everything you need.
The maturity of peptide microarray technology has made a quantum leap in biological research. This technology has also been widely used in vaccine development and tumor research, as well as contributes a lot especially in the field of epitope mapping, tumor neoantigen discovery. It is foreseeable that the flexible application of peptide microarray technology will superspeed the discovery and identification of epitopes, which are essential components of vaccines, more efficient, compared to the previous methods of screening for overlapping peptide libraries that consume a lot of human and financial resources. The ability to discover tumor neoepitopes will also greatly accelerate the development of tumor vaccines, especially the advancement of individualized neoantigen tumor vaccines.
Features of our Custom Peptide Microarray
- High throughput and high resolution
- Ability to respond flexibly to different needs
- Excellent noise reduction performance
- Rigorous operation and strict quality control
- Powerful and professional analytical services
- Cost-effective
- Complete and consistent technical support
Combined with the latest peptide laser printing technology and advanced detection methods, Creative Biolabs has ingeniously optimized peptide microarray technology, a powerful tool for vaccine research, enabling it to play a greater role in vaccine development. We are therefore capable of providing our customers with quality customized peptide microarray service to help you save time and effort in vaccine development as well as get you one step ahead of your peers.
Reference
- Foong YM and Fu J. (2012). “Current advances in peptide and small molecule microarray technologies” Curr Opin Chem Biol.16(1-2), 234-42.
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
