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A uniCAR [Avidin-BBζ], with a CAR Adaptor [Biotinylated Anti-MUC1 Antibody (BOS7D10)], a BBIR CAR System (CAR-NR-ZP182)

The biotin-binding immune receptors (BBIR) CAR use the biotin-avidin "lock-key" mechanism for CAR engineering. The BBIR containing dimeric avidin (dcAv BBIR) is used as the extracellular domain linked to an intracellular T cell signaling domain. Avidin was able to efficiently recognize and bind a variety of biotinylated antigen-specific molecules. The biotinylated antigen can be customized as scFv, mAb or tumor-specific ligand. Creative Biolabs provides customized BBIR design and construction services. Please contact us for more detailed information.

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CAR Schemeitc

UniCAR

  • CAR Construction
  • Avidin-41BB-CD3ζ
  • Discription of Signaling Cassetes
  • 41BB
    CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. On the basis of preclinical observation, this molecule can promote the persistence of antigen-specific and antigennonspecific chimeric antigen receptor T-cells to significantly increases antitumor activity.
    CD3ζ
    CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric 4-1BB and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.
  • Vector Name
  • pCDCAR1
  • Vector length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Targeting Diseases
  • Colorectal cancer

CAR Adaptor

  • Adaptor Target
  • MUC1
  • Common Name
  • MUC1
  • Adaptor Type
  • Biotinylated Antibody
  • Antibody Host
  • Mouse
  • Antibody Clone
  • BOS7D10
  • CAR Adaptor Tag
  • Biotin

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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