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Anti-3′-deoxy α-GalCer T cell receptor (9B2), pCDTCR1 (TCR-YC0035)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-3′-deoxy α-GalCer T cell receptor (TCR) is constructed for the engineering of T cell to target 3′-deoxy α-GalCer restricted by human CD1d. The T cells are genetically modified through transduction with a lentiviral vector expressing 3′-deoxy α-GalCer-specific T cell receptor.

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Details

  • Target
  • 3′-deoxy α-GalCer
  • Epitope
  • 3′-deoxy α-GalCer
  • Format
  • Non-Modified TCR
  • Allele
  • human CD1d
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • 9B2
  • Host Species
  • Human

Target

  • Introduction
  • αβ T cells can be activated by peptides, metabolites and lipids when bound to their requisite antigen (Ag)-presenting molecules. The CD1 family of MHC-class I-like molecules present an array of endogenous and foreign lipids Ags that are recognized by specialized T-cell populations. For example, NKT cells are activated by lipid-based Ags presented by CD1d. Based on ligand specificity and αβ TCR composition, NKT cells are broadly sub-divided into two populations, type I and II. α-Galactosylceramide (α-GalCer) is the prototypical Ag for type I NKT cells, which express an invariant TCR α-chain (TRAV10+TRAJ18+ (Vα24-Jα18) in humans and the orthologous TRAV11+TRAJ18+ (Vα14-Jα18) in mice). While type II NKT cells display a diverse TCR repertoire, and while their Ag-specificity remains unclear, they are nevertheless characterized as being non-reactive towards α-GalCer. The apparent functional divergence between type I and type II NKT cells arises, in part, from the interaction between the NKT TCR and CD1d–Ag.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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