Anti-BRAF DNA-encoded mAb (DMAb), pVAX1 (DMAb-0175-YY)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product is the plasmid containing an encoded anti-BRAF DMAb sequence. The plasmid can drive transcription and in vivo translation of the desired antibody.

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Specifications

Target
BRAF

Vector Name
pVAX1

Vector Description
pVAX1 was originally designed for the development of DNA vaccines. Its eukaryotic DNA sequences limited to the expression of desired sequence so that minimize the possibility of chromosomal integration. This vector has been widely used for the construction of DMAb plasmid.

Vector Promoter
CMV

Vector Tag or Fusion
Untagged

Delivery Method
Transfection

Cloning Method
Restriction Enzyme ⁄ MCS

Constitutive or Inducible System
Constitutive

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Background
DNA-encoded mAb (DMAb) technology is a novel approach for a direct in vivo production of desired biologically active immunoglobulins according to the plasmid DNA delivery into tissue where the delivered plasmid containing an encoded antibody sequence. Compared with the traditional mAb, DMAb can be functionally equivalent with additional advantages such as expression profiles, glycosylation, as well as no reliance on in vivo tissue culture and costly or time-consuming production systems. The DMAb technology may provide a novel, simple, less frequent, cost-effective approach for therapeutics.

Target

Entrez Gene ID
673

UniProt ID
P15056

Sub CAT.	DMAb Clone	DMAb Host	Target Species	DMAb Isotype	DMAb Immunogen
DMAb-0175-YY	CBYY-0741	Mouse	Human	IgG1	Recombinant protein
DMAb-0176-YY	CBYY-0742	Mouse	Human	IgG1	Purified recombinant fragment of human BRAF expressed in E. coli
DMAb-0177-YY	CBYY-0743	Mouse	Human	IgG1	Purified recombinant fragment of human BRAF expressed in E. coli
DMAb-0178-YY	CBYY-0744	Mouse	Human		Recombinant corresponding to humn B-Raf expressed in E.coli
DMAb-0179-YY	CBYY-0745	Rabbit	Human	IgG1
DMAb-0180-YY	CBYY-0746	Rabbit	Human		BRAF (NP_004324, 138aa-231aa) full length recombinant protein with GST tag. MW of the GST tag alone is 26kD
DMAb-0181-YY	CBYY-0747	Mouse	Human	IgG2b	This antibody detects endogenous levels of BRAF and does not cross-react with related proteins
DMAb-0182-YY	CBYY-0748	Mouse	Human	IgG2b	BRAF antibody was raised in mouse using a full length recombinant protein of human BRAF (NP_004324) produced in HEK293T cells, as the immunogen
DMAb-0183-YY	CBYY-0749	Mouse	Human	IgG1, κ	Partial recombinant corresponding to aa346-445 from human BRAF (NP_004324) with GST tag. MW of the GST tag alone is 26kD
DMAb-0184-YY	CBYY-0750	Mouse	Chicken		BRAF (NP_004324, 138aa-231aa) full length recombinant protein with GST tag. MW of the GST tag alone is 26kD
DMAb-0185-YY	CBYY-0751	Mouse	Human		BRAF (NP_004324, 138aa-231aa) full length recombinant protein with GST tag. MW of the GST tag alone is 26kD
DMAb-0186-YY	CBYY-0752	Mouse	Human		BRAF (NP_004324, 138aa-231aa) full length recombinant protein with GST tag. MW of the GST tag alone is 26kD
DMAb-0187-YY	CBYY-0754	Mouse	Human	IgG1, κ	Synthetic peptide derived from the mid region of human B-Raf
DMAb-0188-YY	CBYY-0756	Mouse	Human	IgG1	Full length human recombinant protein of human BRAF (NP_004324) produced in HEK293T cell
DMAb-0189-YY	CBYY-0757	Mouse	Human	IgG1	Full length human recombinant protein of human BRAF (NP_004324) produced in HEK293T cell
DMAb-0190-YY	CBYY-0758	Mouse	Human	IgG1	Full length human recombinant protein of human BRAF (NP_004324) produced in HEK293T cell
DMAb-0191-YY	CBYY-0759	Mouse	Human	IgG2a	Full-length protein expressed in 293T cell transfected with human BRAF expression vector
DMAb-0192-YY	CBYY-0760	Mouse	Human	IgG1	Full-length protein expressed in 293T cell transfected with human BRAF expression vector
DMAb-0193-YY	CBYY-0761	Mouse	Human	IgG2b	Full length human recombinant protein of human BRAF (NP_004324) produced in HEK293T cell
DMAb-0194-YY	CBYY-0762	Rabbit	Mouse	IgG2a	Full-length protein expressed in 293T cell transfected with human BRAF expression vector
DMAb-0195-YY	CBYY-0763	Mouse	Rat	IgG2a	Full-length protein expressed in 293T cell transfected with human BRAF expression vector
DMAb-0196-YY	CBYY-0764	Mouse	Rat	IgG1	Full-length protein expressed in 293T cell transfected with human BRAF expression vector
DMAb-0197-YY	CBYY-0765	Mouse	Rat	IgG1	Full-length protein expressed in 293T cell transfected with human BRAF expression vector
DMAb-0198-YY	CBYY-0766	Mouse	Rat	IgG1	Full length human recombinant protein of human BRAF (NP_004324) produced in HEK293T cell
DMAb-0199-YY	CBYY-0773	Mouse	Human	IgG1	Purified recombinant fragment of BRAF (AA: 285-401) expressed in E. coli
DMAb-0424-YY	CBYY-1735	Rabbit	Human	IgG2a	E. coli-derived recombinant human B-Raf, Met1-His766, Accession # P15056
DMAb-0404-YY	CBYY-1674	Rat	Mouse	IgG1	Full length human recombinant protein of human BRAF (NP_004324) produced in HEK293T cell
DMAb-0437-YY	CBYY-1785	Rat	Mouse	IgG2b	Protein expressed in 293T cell transfected with human BRAF expression vector
DMAb-0439-YY	CBYY-1787	Mouse	Human		BRAF (NP_004324, 138aa-231aa) full length recombinant protein with GST tag. MW of the GST tag alone is 26kD
DMAb-0462-YY	CBYY-1860	Mouse	Chicken	IgG1, κ	This BRAF Monoclonal antibody is generated from mouse immunized with BRAF recombinant protein
DMAb-0477-YY	CBYY-1901	Mouse	Human	IgG1	Full length human recombinant protein of human BRAF (NP_004324) produced in HEK293T cell
DMAb-0467-YY	CBYY-1867	Mouse	Human	IgG2a	Human B-Raf aa. 285-406
DMAb-0468-YY	CBYY-1868	Mouse	Human	IgG2b	Purified recombinant human BRAF protein fragments expressed in E. coli
DMAb-0486-YY	CBYY-1926	Mouse	Cat	IgG1
DMAb-0487-YY	CBYY-1927	Mouse	Cat	IgG1	Purified recombinant fragment of BRAF expressed in E. Coli
DMAb-0488-YY	CBYY-1928	Mouse	Human	IgG1	Purified recombinant fragment of BRAF expressed in E. Coli
DMAb-0481-YY	CBYY-1918	Mouse	Human	IgG2a	Protein expressed in 293T cell transfected with human BRAF expression vector
DMAb-0526-YY	CBYY-2040	Hamster	Mouse		BRAF (NP_004324, 346aa-445aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD
DMAb-0534-YY	CBYY-2082	Mouse	Human	IgG2a
DMAb-0532-YY	CBYY-2077	Mouse	Human	IgG2a	Protein expressed in 293T cell transfected with human BRAF expression vector
DMAb-0538-YY	CBYY-2093	Mouse	Human	IgG1	Protein expressed in 293T cell transfected with human BRAF expression vector
DMAb-0536-YY	CBYY-2086	Mouse	Human	IgG1	Protein expressed in 293T cell transfected with human BRAF expression vector
DMAb-0541-YY	CBYY-2100	Rat	Mouse	IgG2a
DMAb-0484-YY	CBYY-1923	Mouse	Human	IgG2b	Protein expressed in 293T cell transfected with human BRAF expression vector
DMAb-0518-YY	CBYY-2023	Rat	Human		BRAF (NP_004324, 138aa-231aa) full length recombinant protein with GST tag. MW of the GST tag alone is 26kD
DMAb-0519-YY	CBYY-2024	Mouse		IgG2a	Protein expressed in 293T cell transfected with human BRAF expression vector
DMAb-0520-YY	CBYY-2029	Mouse	Human	IgG1	Protein expressed in 293T cell transfected with human BRAF expression vector
DMAb-0522-YY	CBYY-2034	Mouse	Human	IgG1	Protein expressed in 293T cell transfected with human BRAF expression vector
DMAb-0545-YY	CBYY-2108	Mouse	Human	IgG1	Protein expressed in 293T cell transfected with human BRAF expression vector

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-BRAF DNA-encoded mAb (DMAb), pVAX1 (DMAb-0175-YY)

Specifications

Target

Customer Reviews and Q&As

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