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Anti-env (RGPGRAFVTI) TCR, pMSGV1 (TCR-L033)

The vector of anti-gp160 T cell receptor (TCR) is constructed for the engineering of T cell to target HIV gp160 . The T cells are genetically modified through transduction with a retroviral vector expressing gp160 -specific T cell receptor. And the vector product was designed for the treatment of AIDS.

Details

  • Target
  • gp160
  • Target Species
  • HIV
  • Epitope
  • RGPGRAFVTI
  • Format
  • Non-modified TCR
  • Targeting Diseases
  • AIDS
  • Vector Name
  • pMSGV1
  • Vector Length
  • 6700-8070bp
  • Vector Type
  • retroviral vector
  • Antibody Host
  • Mouse

Target

  • Gene Name
  • Envelope glycoprotein
  • Official Symbol
  • env
  • Synonyms
  • MLVgp1; Envelope glycoprotein
  • Introduction
  • The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes the
    acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of
    the immune system allows life-threatening opportunistic infections and cancers to thrive. Without
    treatment, average survival time after infection with HIV is estimated to be 9 to 11 years, depending
    on the HIV subtype. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, preejaculate,
    or breast milk. Within these bodily fluids, HIV is present as both free virus particles and
    virus within infected immune cells.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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