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Anti-KCNB1 T cell receptor, pCDTCR1 (TCR-ZP607)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-KCNB1 T cell receptor (TCR) is constructed for the engineering of T cell to target Human. The T cells are genetically modified through transduction with a lentiviral vector expressing KCNB1-specific T cell receptor. And the vector product was designed for the treatment of Breast cancer.

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Details

  • Target
  • KCNB1
  • Target Species
  • Human
  • Epitope
  • LLAILPYYV
  • Format
  • Non-modified
  • Allele
  • HLA-DRB5
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • Breast cancer
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • MH11
  • Host Species
  • Human

Target

  • Introduction
  • Voltage gated potassium (Kv) channels represent the most complex class of voltage gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence related potassium channel genes shaker, shaw, shab, and shal have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage gated, shab related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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