Anti-LAG3 DNA-encoded mAb (DMAb), pVAX1 (DMAb-4014-FY)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product is the plasmid containing an encoded anti-LAG3 DMAb sequence. The plasmid can drive transcription and in vivo translation of the desired antibody.

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Specifications

Target
LAG3

Vector Name
pVAX1

Vector Description
pVAX1 was originally designed for the development of DNA vaccines. Its eukaryotic DNA sequences limited to the expression of desired sequence so that minimize the possibility of chromosomal integration. This vector has been widely used for the construction of DMAb plasmid.

Vector Promoter
CMV

Vector Tag or Fusion
Untagged

Delivery Method
Transfection

Cloning Method
Restriction Enzyme ⁄ MCS

Constitutive or Inducible System
Constitutive

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Background
DNA-encoded mAb (DMAb) technology is a novel approach for a direct in vivo production of desired biologically active immunoglobulins according to the plasmid DNA delivery into tissue where the delivered plasmid containing an encoded antibody sequence. Compared with the traditional mAb, DMAb can be functionally equivalent with additional advantages such as expression profiles, glycosylation, as well as no reliance on in vivo tissue culture and costly or time-consuming production systems. The DMAb technology may provide a novel, simple, less frequent, cost-effective approach for therapeutics.

Target

Entrez Gene ID
3902

UniProt ID
P18627

Sub CAT.	DMAb Clone	DMAb Host	Target Species	DMAb Isotype	DMAb Immunogen
DMAb-0799-YJ	12K124	Rat	Mouse	IgG2b	Recognizes mouse LAG-3. Does not react with recombinant human LAG-3.
DMAb-0800-YJ	7E155	Rat	Mouse	IgG1	Murine CD223 Ig fusion protein.
DMAb-0801-YJ	C9B7W	Rat	Mouse	IgG1	Murine CD223 Ig fusion protein. Cells from immunised Lewis rats were fused with cells of the Sp/20 myeloma cell line.
DMAb-0734-YJ	11E3	Mouse		IgG1	Recombinant human LAG-3.
DMAb-0735-YJ	17B4	Mouse	Human	IgG1	Synthetic peptide corresponding to 30 aa in the N-terminus of human LAG-3.
DMAb-0736-YJ	3C39	Mouse	Human	IgG2	Human recombinant LAG-3.
DMAb-0737-YJ	5C3	Mouse	Human	IgG2b
DMAb-0738-YJ	6D511	Mouse		IgG1	Recognizes the first N-terminal D1 domain of human LAG-3. Species Crossreactivity: monkey.
DMAb-0739-YJ	6D65	Mouse	Human	IgG1	Synthetic peptide corresponding to 30AA, GPPAAAPGHPLAPGPHPAAPSSWGPRPRRY from the first N-terminal D1 domain of human LAG-3 (lymphocyte activation gene-3).
DMAb-0740-YJ	8F6	Mouse	Human	IgG2b	Human recombinant protein fragment corresponding to amino acids 66-332 of human LAG3 (NP_002277) produced in E.coli.
DMAb-0741-YJ	8G6	Mouse	Human	IgG2b	Human recombinant protein fragment corresponding to amino acids 66-332 of human LAG3(NP_002277) produced in E. coli.ImmunogenType: Recombinant protein.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-LAG3 DNA-encoded mAb (DMAb), pVAX1 (DMAb-4014-FY)

Specifications

Target

Customer Reviews and Q&As

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