Anti-MGMT DNA-encoded mAb (DMAb), pVAX1 (DMAb-2230-FY)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product is the plasmid containing an encoded anti-MGMT DMAb sequence. The plasmid can drive transcription and in vivo translation of the desired antibody.

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Specifications

Target
MGMT

Vector Name
pVAX1

Vector Description
pVAX1 was originally designed for the development of DNA vaccines. Its eukaryotic DNA sequences limited to the expression of desired sequence so that minimize the possibility of chromosomal integration. This vector has been widely used for the construction of DMAb plasmid.

Vector Promoter
CMV

Vector Tag or Fusion
Untagged

Delivery Method
Transfection

Cloning Method
Restriction Enzyme ⁄ MCS

Constitutive or Inducible System
Constitutive

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Background
DNA-encoded mAb (DMAb) technology is a novel approach for a direct in vivo production of desired biologically active immunoglobulins according to the plasmid DNA delivery into tissue where the delivered plasmid containing an encoded antibody sequence. Compared with the traditional mAb, DMAb can be functionally equivalent with additional advantages such as expression profiles, glycosylation, as well as no reliance on in vivo tissue culture and costly or time-consuming production systems. The DMAb technology may provide a novel, simple, less frequent, cost-effective approach for therapeutics.

Target

Entrez Gene ID
4255

UniProt ID
P16455

Sub CAT.	DMAb Clone	DMAb Host	Target Species	DMAb Isotype	DMAb Immunogen
DMAb-2230-FY	CBFYM-0373	Mouse	Human	IgG2b	Recombinant human MGMT (O6-methylguanine-DNA methyltransferase) purified from E. coli
DMAb-2231-FY	CBFYM-0517	Mouse	Human	IgG3
DMAb-2232-FY	CBFYM-0634	Mouse	Human	IgG1
DMAb-2233-FY	CBFYM-0635	Mouse	Human	IgG1
DMAb-2234-FY	CBFYM-0636	Mouse	Human	IgG2b
DMAb-2235-FY	CBFYM-0637	Mouse	Human	IgG3, k
DMAb-2236-FY	CBFYM-2182	Mouse	Human	IgG1, k
DMAb-2237-FY	CBFYM-2183	Mouse	Human	IgG1	Recombinant human MGMT (O6-methylguanine-DNA methyltransferase) expressed in E. coli
DMAb-2238-FY	CBFYM-2184	Mouse	Human	IgG3, k	Partial recombinant corresponding to aa1-100 from human MGMT (AAH00824) with GST tag. MW of the GST tag alone is 26kD.
DMAb-2239-FY	CBFYM-2185	Mouse	Human	IgG1	Full length human recombinant protein of human MGMT (NP_002403) produced in E.coli
DMAb-2240-FY	CBFYM-2186	Rat	Mouse	IgG2a	E. coli-derived recombinant mouse MGMT, Met1-Asn211

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-MGMT DNA-encoded mAb (DMAb), pVAX1 (DMAb-2230-FY)

Specifications

Target

Customer Reviews and Q&As

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