Anti-NES DNA-encoded mAb (DMAb), pVAX1 (DMAb-1363-WJ)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product is the plasmid containing an encoded anti-NES DMAb sequence. The plasmid can drive transcription and in vivo translation of the desired antibody.

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Specifications

Target
NES

Vector Name
pVAX1

Vector Description
pVAX1 was originally designed for the development of DNA vaccines. Its eukaryotic DNA sequences limited to the expression of desired sequence so that minimize the possibility of chromosomal integration. This vector has been widely used for the construction of DMAb plasmid.

Vector Promoter
CMV

Vector Tag or Fusion
Untagged

Delivery Method
Transfection

Cloning Method
Restriction Enzyme ⁄ MCS

Constitutive or Inducible System
Constitutive

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Background
DNA-encoded mAb (DMAb) technology is a novel approach for a direct in vivo production of desired biologically active immunoglobulins according to the plasmid DNA delivery into tissue where the delivered plasmid containing an encoded antibody sequence. Compared with the traditional mAb, DMAb can be functionally equivalent with additional advantages such as expression profiles, glycosylation, as well as no reliance on in vivo tissue culture and costly or time-consuming production systems. The DMAb technology may provide a novel, simple, less frequent, cost-effective approach for therapeutics.

Target

Entrez Gene ID
10763

UniProt ID
P48681

Sub CAT.	DMAb Clone	DMAb Host	Target Species	DMAb Isotype	DMAb Immunogen
DMAb-1366-WJ	10C2	Mouse	Human	IgG1, κ	A fragment of the human Nestin protein corresponding to residues 1464-1614.
DMAb-1368-WJ	2C1.3A11	Mouse	Human	IgG1
DMAb-1381-WJ	1A9G12	Mouse	Human	IgG1
DMAb-1381-WJ	1A9G12	Mouse	Human	IgG2b	Purified recombinant fragment of human NES (amino acids: 419-588 ) expressed in E. Coli
DMAb-1381-WJ	1A9G12	Mouse	Human	IgM	Purified recombinant fragment of human NESTIN (AA: 419-588 ) expressed in E. Coli
DMAb-0018-CN	1B4	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 99-349 of human NES(NP_006608) produced in E.coli
DMAb-1385-WJ	1D11H2	Mouse		IgG2b
DMAb-1388-WJ	3k1	Mouse	Human	IgG1	NS0 cells transfected with human Nestin. Uni.
DMAb-1168-WJ	4D11	Mouse		IgG1	A preparation of a segment of recombinant human Nestin (amino acids 317 to 630) expressed in bacteria and highly purified
DMAb-0734-YY	4D4	Mouse		IgG
DMAb-1391-WJ	5C93	Mouse	Human	IgG1	Synthetic peptide corresponding to 150aa fragment from human nestin conjugated to glutathione S-transferase
DMAb-689-YC	7A3	Rat	Mouse	IgG2b
DMAb-1393-WJ	9A19	Mouse	Human	IgG1, κ	Recognizes human nestin. It does not crossreact with rodent protein
DMAb-1395-WJ	GT623	Mouse		IgG1	Recombinant protein encompassing a sequence within the C-terminus region of human Nestin. The exact sequence is proprietary

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-NES DNA-encoded mAb (DMAb), pVAX1 (DMAb-1363-WJ)

Specifications

Target

Customer Reviews and Q&As

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