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Anti-NY-ESO-1 TCR-ABR-β (XW-300) CAR Vector (XS-1122-YF2140)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-NY-ESO-1 TCR-fused Antigen Binding Receptor (TCR-ABR) CAR is constructed for the engineering of T cells to target Human NY-ESO-1. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv (XW-300) of anti-NY-ESO-1 antibody linked to TCRβ subunit. The vector product was designed for the discovery and development of cellular therapy against New York esophageal squamous cell carcinoma. The TCR-ABR can effectively reprogram an intact TCR complex to recognize tumor surface antigens. TCR-ABR-T cells are shown to engage the signaling capacity of the entire TCR complex in an HLA-independent manner.

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Details

  • Target
  • NY-ESO-1
  • Targeting Cell Type
  • T Cell
  • Targeting Diseases
  • New York esophageal squamous cell carcinoma
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Receptor Construction
  • scFv-TCRβ
  • Discription of Signaling Cassetes
  • The scFv used to generate CAR-T cells or single domain antibodies can be fused to the extracellular N-termini of TCRα, TCRβ, CD3γ, CD3δ, or CD3ε subunits, resulting in the activation of target-specific TCR-ABR-T cells. TCR-ABR-T cells have been shown to use the entire TCR complex's signaling capacity in an HLA-independent manner.

Target

  • Clone
  • XW-300
  • Host
  • Mouse
  • Target Species
  • Human
  • Gene Name
  • cancer/testis antigen 1B
  • Synonyms
  • CTAG; ESO1; CT6.1; CTAG1; LAGE-2; LAGE2B; NY-ESO-1
  • Introduction
  • The protein encoded by this gene is an antigen that is overexpressed in many cancers but that is also expressed in normal testis. This gene is found in a duplicated region of the X-chromosome and therefore has a neighboring gene of identical sequence.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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