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Anti-OVAL (SQAVHAAHAEINEAGR) TCR, pLXSN (TCR-L086)

The vector of anti-OVA T cell receptor (TCR) is constructed for the engineering of T cell to target OVA. The T cells are genetically modified through transduction with a retroviral vector expressing OVA-specific T cell receptor. And the vector product was designed for the treatment of Food allergy.

Details

  • Target
  • OVA
  • Target Species
  • Chicken
  • Epitope
  • SQAVHAAHAEINEAGR
  • Format
  • Non-modified TCR
  • Targeting Diseases
  • Food allergy
  • Vector Name
  • pLXSN
  • Vector Length
  • 6714-6688bp
  • Vector Type
  • retroviral vector
  • Antibody Host
  • Human

Target

  • Gene Name
  • ovalbumin (SERPINB14)
  • Official Symbol
  • OVAL
  • Synonyms
  • Tra-P1A; Trap1a; tumor rejection antigen P1A; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Spleen cancer; thymus cancer; liver cancer; lung cancer
  • Introduction
  • This peptide is amino acids 323 to 339 amidated fragment of ovalbumin (OVA), the H-2b-restricted
    OVA class II epitope. This peptide is recognized by many T cells because it contains multiple T cell
    epitopes. This OVA fragment contains a nested set of CD4+ T cell epitopes. OVA 323 to 339 can be
    presented by I-Ad in at least three binding registers. The residues 327 to 333 are critical for peptide
    binding to I-Ad

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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