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anti-p21 protein (aa53-61) TCR, pCDTCR1(TCR-L073Z)

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The vector of anti-p21 protein T cell receptor (TCR) is constructed for the engineering of T cell to target Human p21 protein. The T cells are genetically modified through transduction with a retroviral vector expressing p21 protein-specific T cell receptor.

Details

Target
p21 protein
Target Species
Human
Epitope
LDILDTAGL
Format
Non-modified
HLA
HLA-A2.1
Vector Name
pCDTCR1
Vector Length
8kb
Vector Type
Lentiviral
Antibody Host
Human

Target

Gene Name
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Official Symbol
CDKN1A
Gene ID
1026
UniProt ID
P38936
Synonyms
P0; CHM; DSS; MPP; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; CMTDID; HMSNIB; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Autoimmune peripheral neuropathy
Introduction
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-097-1828

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