Anti-SHC1 DNA-encoded mAb (DMAb), pVAX1 (DMAb-2331-CQ)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product is the plasmid containing an encoded anti-SHC1 DMAb sequence. The plasmid can drive transcription and in vivo translation of the desired antibody.

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Specifications

Target
SHC1

Vector Name
pVAX1

Vector Description
pVAX1 was originally designed for the development of DNA vaccines. Its eukaryotic DNA sequences limited to the expression of desired sequence so that minimize the possibility of chromosomal integration. This vector has been widely used for the construction of DMAb plasmid.

Vector Promoter
CMV

Vector Tag or Fusion
Untagged

Delivery Method
Transfection

Cloning Method
Restriction Enzyme ⁄ MCS

Constitutive or Inducible System
Constitutive

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Background
DNA-encoded mAb (DMAb) technology is a novel approach for a direct in vivo production of desired biologically active immunoglobulins according to the plasmid DNA delivery into tissue where the delivered plasmid containing an encoded antibody sequence. Compared with the traditional mAb, DMAb can be functionally equivalent with additional advantages such as expression profiles, glycosylation, as well as no reliance on in vivo tissue culture and costly or time-consuming production systems. The DMAb technology may provide a novel, simple, less frequent, cost-effective approach for therapeutics.

Target

Entrez Gene ID
6464

UniProt ID
P29353

Sub CAT.	DMAb Clone	DMAb Host	Target Species	DMAb Isotype	DMAb Immunogen
DMAb-2331-CQ	CBXS-5657	Mouse		IgG1	Recombinant human protein purified from E.coli (His/ABD-Shc1)
DMAb-2332-CQ	CBXS-3658	Mouse		IgG1	Synthetic peptide corresponding to the sequence near the C-terminus of Shc
DMAb-2333-CQ	CBXS-3980	Mouse		IgG1	Recombinant full length human SHC1 (NP_003020) produced in HEK293T cell
DMAb-2334-CQ	CBXS-4239	Mouse		IgG1	Recombinant full length human SHC1 (NP_003020) produced in HEK293T cell
DMAb-2335-CQ	CBXS-4289	Mouse		IgG1
DMAb-2336-CQ	CBXS-4604	Mouse		IgG1	Purified recombinant fragment of human SHC1
DMAb-2337-CQ	CBXS-5513	Mouse		IgG1
DMAb-2338-CQ	CBXS-1204	Rabbit		IgG
DMAb-2339-CQ	CBXS-1208	Rabbit		IgG
DMAb-2340-CQ	CBXS-1580	Rabbit		IgG
DMAb-2341-CQ	CBXS-1908	Mouse		IgG1	Recombinant human SHC1, Pro379-Val470, Trp488-Val579, Accession # P29353
DMAb-2342-CQ	CBXS-3096	Mouse		IgG, κ	Recombinant corresponding to aa171-280 from human SHC1 with GST tag
DMAb-2343-CQ	CBXS-3357	Mouse		IgG1	Synthetic peptide corresponding to a portion of N-terminal p66Shc
DMAb-2344-CQ	CBXS-3358	Mouse		IgG1	Synthetic peptide corresponding to a portion of shc

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-SHC1 DNA-encoded mAb (DMAb), pVAX1 (DMAb-2331-CQ)

Specifications

Target

Customer Reviews and Q&As

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