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pCDCAR1 TFAP2B h(BBζ) (CAR-YJ249)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-TFAP2B chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human TFAP2B. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-TFAP2B antibody linked to 4-1BB (CD137) and CD3ζ signaling domains. And the vector product was designed for the treatment of Breast cancer.

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Details

  • Target
  • TFAP2B
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • Breast cancer
  • Generation
  • Second
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Receptor Construction
  • scFv-41BB-CD3ζ
  • Discription of Signaling Cassetes
  • 41BB
    CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. On the basis of preclinical observation, this molecule can promote the persistence of antigen-specific and antigen-nonspecific chimeric antigen receptor T-cells to significantly increases antitumor activity.
    CD3ζ
    CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta,which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.

Target

  • Clone
  • 3G5-1D11
  • Host
  • Mouse
  • Target Species
  • Human
  • Gene Name
  • Transcription Factor AP-2 Beta
  • Synonyms
  • TFAP2B; Transcription Factor AP-2 Beta; AP2-BETA; Transcription Factor AP-2 Beta (Activating Enhancer-Binding Protein 2 Beta); Transcription Factor AP-2 Beta (Activating Enhancer Binding Protein 2 Beta); Activating Enhancer Binding Protein 2 Beta; Activating Enhancer-Binding Protein 2-Beta
  • Introduction
  • TFAP2B is a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. TFAP2B plays a role as both a transcriptional activator and repressor. Mutations in TFAP2B result in autosomal dominant Char syndrome, suggesting that TFAP2B functions in the differentiation of neural crest cell derivatives.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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