Biotinylated Human CLEC12A CAR Detection Reagent, His,Avitag™ (CARD-LX150)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Evaluating CAR expression is an essential step in the production of CAR-T cells. Creative biolabs provides several detection reagents which are uniquely suitable for evaluation of CAR expression. Biotinylated Human CLEC12A CAR Detection Reagent, His,Avitag? is a special detection reagent which is used to detect Human CLEC12A CAR related to the study of AML.

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Specifications

Target
CLEC12A

Application
FC, ELISA

Purity
>90%

Endotoxin Level
Less than 1.0 EU per μg by the LAL method.

Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please protect from light and avoid repeated freeze-thaw cycles.

Application Notes
The optimal working dilutions should be determined by the end user.

Diseases
AML

Molecular Characterization
It contains AA His 65 - Ala 265 (Accession # Q5QGZ9-2).

Conjugation
Biotinylated

Size
200ug

Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Expression
Human HEK293 cells

Host Species
Human

Species Reactivity
Human

Form
lyophilized

Images
Figure 1 Structure

Figure 2 Binding activity Evaluation

Target

Target Introduction
CLEC12A (C-type lectin domain family 12 member A) is also known as CLL1, DCAL2, MICL. Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. Evidence of distinct disease propagating stem cells in myelodysplastic syndrome (MDS) has emerged in recent years. The role of CLEC12A in MDS, however, remains to be elucidated. Furthermore, CLEC12A has been proposed as a promising marker of leukaemic stem cells in AML.

Target Alternative Names
CLEC12A

UniProt ID
Q5QGZ9-2

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Biotinylated Human CLEC12A CAR Detection Reagent, His,Avitag™ (CARD-LX150)

Specific Inquiry

Specifications

Target

Customer Reviews and Q&As

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