Blastoma Specific CAR Construction Service

Struggling with tough, solid tumors, worrying about side effects, or finding your CAR-T cells just aren't sticking around? Don't sweat it! Our blastoma-specific CAR construction service helps you expedite the process and deliver safer, more effective treatments. We utilize advanced CAR engineering and rigorous testing, providing comprehensive, customized solutions to address blastoma challenges from start to finish.

Introduction

Blastoma is a cancer arising from embryonic tissue, more common in children than adults. Based on tumor location, subtypes include medulloblastoma, hepatoblastoma, nephroblastoma, pleuropulmonary blastoma, retinoblastoma, neuroblastoma, and osteoblastoma. Symptoms vary, and treatment often involves surgery, radiation, and chemotherapy, which may cause long-term side effects. Adoptive cell therapy targeting blastoma-specific antigens offers a promising alternative. The chimeric antigen receptor (CAR)-modified T or NK cells have already entered clinical trials for blastoma treatment.

Fig.1 Design of a single-chain variable fragment in CAR-T cells.¹

Blastoma-Specific CAR Construction Service at Creative Biolabs

Creative Biolabs' blastoma-specific CAR construction service delivers bespoke CAR constructs and expertly engineered T cells, providing you with critical solutions to advance your oncology projects. We address key challenges in solid tumor targeting, offering meticulously designed CARs with enhanced specificity and functionality. Our service provides comprehensive preclinical data, empowering you to make informed decisions and accelerate your therapeutic candidates toward clinical translation.

Creative Biolabs has many years of experience in CARs construction for targeting blastoma-specific antigens. We can provide highly customized and best-in-class CAR products according to our special and strict requirements.

• Antibody Sequence Screening and single chain variable fragment (scFv) Construction: We acquire scFv sequences either via de novo antibody development or through public databases and patent literature.
• CAR Structure Design: We assemble CAR constructs by combining a signal peptide, the optimized scFv, a flexible hinge, a transmembrane domain, and intracellular signaling modules.

Service Process

Key Advantages

• Cutting-Edge Platforms: Access to state-of-the-art facilities and proprietary platforms for CAR engineering, viral vector production, and advanced in vitro and in vivo validation.
• Rigorous Quality Control: Our multi-stage QC process ensures high CAR expression, potent cytotoxicity, and optimal cell viability, providing you with reliable and consistent results.
• Commitment to Safety and Efficacy: Our designs prioritize both potent anti-tumor activity and robust safety profiles, incorporating advanced features like conditional suicide genes and dual-receptor systems.

FAQs

Why Choose Us?

Creative Biolabs is dedicated to accelerating the development of life-changing immunotherapies. Our blastoma-specific CAR construction service stands as a testament to our commitment to precision, quality, and innovation in the fight against aggressive solid tumors. By leveraging our deep expertise and state-of-the-art platforms, we empower our partners to achieve breakthroughs faster and more efficiently.

Customer Reviews

"Using Creative Biolabs' blastoma-specific CAR construction service in our glioblastoma research has significantly improved the specificity of our CAR constructs, reducing concerns about off-target effects compared to previous general approaches. Their dual receptor system design was particularly impactful." – 2024, An Sh

"The end-to-end workflow provided by Creative Biolabs, from scFv development to comprehensive QC, greatly facilitated our neuroblastoma CAR-T project. The detailed protocols and consistent results saved us considerable time and resources." – 2023, La Mr

How to Contact Us

Ready to advance your blastoma therapy project? Our expert team is here to provide detailed information and discuss how our tailored solutions can meet your specific needs.

For more information or to discuss your specific project, please reach out to our team.

Products against Blastoma-specific antigens

Please note: If you do not find the wanted antigen, please feel free to contact us. Our highly skilled staff is very glad to help you.

Reference

1. Jayaraman, Jayapriya et al. "CAR-T design: Elements and their synergistic function." EBioMedicine vol. 58 (2020): 102931. https://doi.org/10.1016/j.ebiom.2020.102931. Distributed under Open Access License CC BY 4.0, without modification.