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CellRapeutics™ CD19+ B Cells from Rheumatoid Arthritis Donor (XS-0426-XU5)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product features CD19+ B cells isolated from donors with clinically confirmed Rheumatoid Arthritis (RA). These cells are critical for investigating the loss of peripheral tolerance and the role of autoreactive B cell populations in synovial inflammation. They serve as a robust model for studying B cell-mediated antigen presentation to T cells and the production of rheumatoid factors (RF) and anti-citrullinated protein antibodies (ACPAs) within the context of chronic joint destruction.

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Donor Information

  • Product Name
  • CellRapeutics™ CD19+ B Cells from Rheumatoid Arthritis Donor
  • Cat. No.
  • XS-0426-XU5
  • Donor Age
  • Middle-Aged, Senior
  • Donor Health
  • Clinically diagnosed with Rheumatoid Arthritis according to ACR/EULAR criteria. Donors typically present with systemic inflammatory markers and characteristic autoantibody profiles.
  • Ethnicity
  • Mainly Caucasian and East Asian cohorts.
  • Anticoagulant
  • Heparin or Acid Citrate Dextrose, utilized to mitigate interference from high titers of Rheumatoid Factor and fibrinogen, maintaining optimal cell dispersion and viability.
  • Additional Donor Information
  • Each lot features CD19+ B cells from donors with confirmed Rheumatoid Arthritis. Profiles highlight serological markers, disease activity scores, and history of DMARD or TNF-inhibitor usage, facilitating research into autoantibody production.
  • Clinical Profile
  • Serological status, disease activity score, presence of erosive disease, and current treatment regimen.

Additional Information

  • Medication History
  • Available upon request. Documentation covers use of Conventional Synthetic DMARDs and Biological DMARDs.
  • Formulation
  • Cryopreserved in specialized freezing medium
  • Cell Purity
  • >90%
  • Cell Viability
  • >90%
  • Mycoplasma Testing
  • Negative
  • Sterility Testing
  • Negative
  • Genetic Stability Testing
  • The donor cells maintain their native genetic profile, exhibiting no karyotypic abnormalities or chromosomal instabilities typically associated with prolonged ex vivo expansion.
  • Application
  • Drug Discovery, Immuno-oncology Research
  • Research Use Only
  • RUO
  • Quality Control
  • Each product batch undergoes rigorous testing for purity, viability, and microbial contamination.
  • Storage
  • Upon arrival, immediately transfer the vial to the liquid nitrogen.
  • Shiping
  • Dry Ice
  • Handling Notes
  • Upon thawing, it is recommended to rapidly thaw the cells in a 37°C water bath, followed by the slow addition of pre-warmed culture medium to minimize osmotic shock.
  • Warnings
  • Treat as potentially biohazardous human-derived material and handle strictly under BSL-2 guidelines using appropriate personal protective equipment.
  • Size
  • 1E7 cells/vial, 2.5E7 cells/vial
  • Keywords
  • CellRapeutics™ CD19+ B Cells from Rheumatoid Arthritis Donor, CD19+ B Cells, Rheumatoid Arthritis

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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