CellRapeutics™ CD19⁺ B Cells from Sjogren's Syndrome Donor (XS-0426-XU6)

Name: CellRapeutics™ CD19+ B Cells from Sjogren's Syndrome Donor
SKU: XS-0426-XU6
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Derived from donors suffering from chronic autoimmune exocrinopathy, these CD19⁺ B cells are essential for researchers focusing on glandular epithelial-B cell interactions. The product provides a window into the mechanisms of B cell hyperactivation, ectopic germinal center formation in salivary glands, and the transition of benign lymphoproliferation to malignant lymphoma, a hallmark risk of Sjogren's Syndrome.

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Donor Information

Product Name
CellRapeutics™ CD19⁺ B Cells from Sjogren's Syndrome Donor

Cat. No.
XS-0426-XU6

Donor Age
Middle-Aged

Donor Health
Diagnosed with primary Sjogren's Syndrome. Donors exhibit specific exocrine gland dysfunction profiles and elevated systemic B-cell hyperactivity, often characterized by positive Anti-SSA/Ro or Anti-SSB/La markers.

Ethnicity
Diverse backgrounds available.

Anticoagulant
Acid Citrate Dextrose, specifically chosen to stabilize hypergammaglobulinemia-associated plasma viscosity and prevent non-specific B-cell aggregation during isolation.

Additional Donor Information
Each lot features CD19⁺ B cells from donors with primary Sjogren's Syndrome. Data points include anti-SSA/Ro and anti-SSB/La status, symptom duration, and comorbid autoimmune profiles, supporting investigations into B-cell hyperactivity and glandular infiltration.

Clinical Profile
Classification, autoantibody profile, glandular involvement severity, and history of systemic manifestations.

Additional Information

Medication History
Available upon request. Includes history of symptomatic treatments, hydroxychloroquine, and any systemic immunosuppressive or biological interventions used for extraglandular manifestations.

Formulation
Cryopreserved in specialized freezing medium

Cell Purity
>90%

Cell Viability
>90%

Mycoplasma Testing
Negative

Sterility Testing
Negative

Genetic Stability Testing
The donor cells maintain their native genetic profile, exhibiting no karyotypic abnormalities or chromosomal instabilities typically associated with prolonged ex vivo expansion.

Application
Drug Discovery, Immuno-oncology Research

Research Use Only
RUO

Quality Control
Each product batch undergoes rigorous testing for purity, viability, and microbial contamination.

Storage
Upon arrival, immediately transfer the vial to the liquid nitrogen.

Shiping
Dry Ice

Handling Notes
Upon thawing, it is recommended to rapidly thaw the cells in a 37°C water bath, followed by the slow addition of pre-warmed culture medium to minimize osmotic shock.

Warnings
Treat as potentially biohazardous human-derived material and handle strictly under BSL-2 guidelines using appropriate personal protective equipment.

Size
1E7 cells/vial, 2.5E7 cells/vial

Keywords
CellRapeutics™ CD19⁺ B Cells from Sjogren's Syndrome Donor, CD19⁺ B Cells, Sjogren's Syndrome

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.