CellRapeutics™ Leukopak from Pemphigus Donor (XS-0426-XU258)

Name: CellRapeutics™ Leukopak from Pemphigus Donor
SKU: XS-0426-XU258
Rating: 5 (1 reviews)

Online Inquiry Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Sourced from donors with Pemphigus, this Leukopak reflects the systemic autoimmunity directed against desmosomal cadherins. The cell population contains circulating B cells specific for desmogleins and the T-cell help required for their activation. It serves as a rare and critical substrate for studying the breakdown of self-tolerance in the skin and the mechanisms of acantholysis-inducing antibody production.

Specific Inquiry

Add to Cart

Donor Information

Product Name
CellRapeutics™ Leukopak from Pemphigus Donor

Cat. No.
XS-0426-XU258

Donor Age
Middle-Aged

Donor Health
Diagnosed with autoimmune blistering disease. Leukocytes exhibit a loss of B-cell tolerance with expanded autoreactive B-cell clones and T-follicular helper cells specific to desmoglein antigens.

Ethnicity
Diverse backgrounds available.

Anticoagulant
Acid Citrate Dextrose, optimized to maintain the viability of desmoglein-specific B cells and autoantibody-secreting plasma cells.

Additional Donor Information
Each lot features a Leukopak from donors with Pemphigus Vulgaris or Foliaceus. Profiles include anti-desmoglein antibody titers and history of corticosteroid or rituximab therapy.

Clinical Profile
Pemphigus subtype, anti-desmoglein 1/3 antibody titers, Pemphigus Disease Area Index score, and history of systemic corticosteroid or B-cell depletion therapy.

Additional Information

Medication History
Available upon request. Records of systemic corticosteroids and B-cell targeted therapies used to manage bullous manifestations.

Formulation
Cryopreserved or Fresh options available.

Cell Purity
>90%

Cell Viability
>90%

Mycoplasma Testing
Negative

Sterility Testing
Negative

Genetic Stability Testing
The donor cells maintain their native genetic profile, exhibiting no karyotypic abnormalities or chromosomal instabilities typically associated with prolonged ex vivo expansion.

Application
Drug Discovery, Immuno-oncology Research

Research Use Only
RUO

Quality Control
Each product batch is strictly validated for high cellular viability, specific immune cell counts, and pathogen-free safety, ensuring consistent clinical phenotypes and ethical compliance for advanced immunological research.

Storage
Store fresh Leukopaks at 2°C to 8°C for immediate use, cryopreserved samples must be kept in liquid nitrogen vapor phase below -150°C.

Shiping
Dry Ice

Handling Notes
Process fresh cells within 48 hours or perform rapid thawing of cryovials in a 37°C water bath followed by gradual dilution to maximize recovery.

Warnings
Treat as potentially biohazardous human-derived material and handle strictly under BSL-2 guidelines using appropriate personal protective equipment.

Size
Full Bag, Half Bag

Keywords
CellRapeutics™ Leukopak from Pemphigus Donor, Leukopak, Pemphigus

Case Studies

Customer Reviews and Q&As

There are currently no customer reviews or questions for CellRapeutics™ Leukopak from Pemphigus Donor (XS-0426-XU258). Click the button below to contact us or submit your feedback about this product.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.