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CellRapeutics™ Serum from Cryopyrin-Associated Periodic Syndrome Donor (XS-0426-XU61)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This serum is harvested from donors with CAPS, a spectrum of autoinflammatory diseases linked to NLRP3 mutations. It is characterized by elevated systemic levels of pro-inflammatory cytokines, resulting from inflammasome hyperactivation. This product serves as a vital tool for studying innate immune dysregulation and the efficacy of interleukin-1 targeted therapies.

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Donor Information

  • Product Name
  • CellRapeutics™ Serum from Cryopyrin-Associated Periodic Syndrome Donor
  • Cat. No.
  • XS-0426-XU61
  • Donor Age
  • Pediatric, Young Adult
  • Donor Health
  • Diagnosed with CAPS. Serum exhibits highly elevated levels of IL-1 family cytokines and acute-phase reactants, reflecting an autoinflammatory state driven by NLRP3 inflammasome overactivity.
  • Ethnicity
  • Diverse backgrounds available.
  • Anticoagulant
  • None (separated via centrifugation following natural coagulation).
  • Additional Donor Information
  • Each lot features serum from donors with CAPS. Profiles include NLRP3 mutation status, inflammatory cytokine profiles, and frequency of periodic febrile episodes.
  • Clinical Profile
  • Specific syndrome, NLRP3 mutation status, and history of systemic inflammation.

Additional Information

  • Medication History
  • Available upon request. Focuses on history of IL-1 inhibitors and documentation of acute flare frequency.
  • Formulation
  • Frozen
  • Cell Viability
  • Cell-free (no residual erythrocytes or leukocytes).
  • Mycoplasma Testing
  • Negative
  • Sterility Testing
  • Negative
  • Application
  • Drug Discovery, Immuno-oncology Research
  • Research Use Only
  • RUO
  • Quality Control
  • Each serum batch undergoes rigorous IRB-compliant screening, ensuring pathogen-free safety, consistent physicochemical properties, and standardized clinical characterization of disease-specific biomarkers to provide a reliable, high-purity biological matrix.
  • Storage
  • Store at -80°C or below for long-term stability, or at -20°C for up to 6 months, avoid repeated freeze-thaw cycles to preserve product quality.
  • Shiping
  • Dry Ice
  • Handling Notes
  • Thaw slowly on ice or at 4°C and centrifuge to remove cryoprecipitates, immediate aliquoting upon first thaw is recommended to maintain autoantibody functional integrity.
  • Warnings
  • Treat as potentially biohazardous human-derived material and handle strictly under BSL-2 guidelines using appropriate personal protective equipment.
  • Size
  • 1ML
  • Keywords
  • CellRapeutics™ Serum from Cryopyrin-Associated Periodic Syndrome Donor, Serum, Cryopyrin-Associated Periodic Syndrome

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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