pCDCAR1 CLEC12A h(CTLA4ζ)(CAR-MZ002)
The vector of anti-CLEC12A chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human CLEC12A. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-CLEC12A antibody linked to CTLA4 and CD3ζ signaling domains. And the vector product was designed for the treatment of Acute myeloid leukemia.
Targeting Cell Type
Acute myeloid leukemia
Discription of Signaling Cassetes
CTLA4 or CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152 (cluster of differentiation 152), is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses. CTLA4 is constitutively expressed in Tregs but only upregulated in conventional T cells after activation. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells.
CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.
C-type lectin domain family 12, member A
CLEC12A; C-type lectin domain family 12; member A; CLL1; MICL; CLL-1; DCAL-2; C-type lectin domain family 12 member A; C-type lectin protein CLL-1; C-type lectin-like molecule-1; dendritic cell-associated lectin 2; myeloid inhibitory C-type lectin-like receptor; anti-CLEC12A
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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