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Anti-CD16A T cell receptor (V158), pCDTCR1 (TCR-ZP014)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-CD16A T cell receptor (TCR) is constructed for the engineering of T cell to target Human CD16A. The T cells are genetically modified through transduction with a lentiviral vector expressing CD16A-specific T cell receptor. And the vector product was designed for the treatment of B cell malignancy.

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Details

  • Target
  • CD16A
  • Target Species
  • Human
  • Format
  • Chimeric TCR
  • Targeting Diseases
  • B cell malignancy
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • V158
  • Host Species
  • Human

Target

  • Official Symbol
  • FCGR3A
  • Introduction
  • This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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