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Anti-CAMEL T cell receptor (2/52), pCDTCR1 (TCR-C021Z)

The vector of anti-CAMEL T cell receptor (TCR) is constructed for the engineering of T cell to target Human CAMEL. The T cells are genetically modified through transduction with a lentiviral vector expressing CAMEL-specific T cell receptor. And the vector product was designed for the treatment of Cancer.

Details

  • Target
  • CAMEL
  • Target Species
  • Human
  • Epitope
  • aa 19-27 (AAQERRVPR)
  • Format
  • Non-modified
  • HLA
  • HLA-DR
  • Targeting Diseases
  • Melanoma, breast cancer, bladder cancer and prostate cancer
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral
  • Antibody Clone
  • 2/52
  • Antibody Host
  • Human

Target

  • Gene Name
  • cancer/testis antigen 2
  • Official Symbol
  • CTAG2
  • Synonyms
  • CT2; ESO2; CAMEL; CT6.2; CT6.2a; CT6.2b; LAGE-1; LAGE2B
  • Introduction
  • This gene encodes an autoimmunogenic tumor antigen that belongs to the ESO/LAGE family of cancer-testis antigens. This protein is expressed in a wide array of cancers including melanoma, breast cancer, bladder cancer and prostate cancer. This protein is also expressed in normal testis tissue. An alternative open reading frame product of this gene has been described in PMID:10399963. This alternate protein, termed CAMEL, is a tumor antigen that is recognized by melanoma-specific cytotoxic T-lymphocytes. Alternate splicing results in multiple transcript variants.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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