Anti-CMV pp65 T cell receptor (TCRCD4-CMV#3), pCDTCR1(TCR-L149)

The vector of anti-CMV pp65 T cell receptor (TCR) is constructed for the engineering of T cell to target CMV CMV pp65. The T cells are genetically modified through transduction with a lentiviral vector expressing CMV pp65-specific T cell receptor. And the vector product was designed for the treatment of HCMV infection.


Details


Target
CMV pp65
Target Species
CMV
Epitope
VELRQYDPVAALFFFDIDLLLQR
Format
Non-modified
HLA
HLA-DRB1*0701
Targeting Diseases
HCMV infection
Vector Name
pCDTCR1
Vector Length
~8kb
Vector Type
Lentiviral
Antibody Clone
TCRCD4-CMV#3
Antibody Host
Human

Target


Gene Name
Tegument protein pp65
Official Symbol
pp65
Synonyms
65 kDa matrix phosphoprotein; 65 kDa phosphoprotein; Tegument protein pp65; Tegument protein UL83
Introduction
Cytomegalovirus is a member of the herpes virus group, which includes herpes simplex virus types 1 and 2, varicella zoster virus (which causes chicken pox), and Epstein Barr virus (which causes infectious mononucleosis). These viruses share a characteristic ability to remain dormant within the body over a long period. CMV viral genes are co-ordinately expressed in groups at various times after infection. Early viral proteins are expressed in the nucleus of infected cells within 3 to 24 hours of infection prior to the commencement of viral DNA replication. This is followed by expression of the early intermediate genes, which encode enzymes required for viral DNA replication. After 48 to 72 hours, a number of late viral antigens may be demonstrated in the nuclei and cytoplasm of infected cells. pp65 is a 65kD phosphorylated glycoprotein and is the most abundant of the late antigens.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Products


Cat# Description
VP-TCR-C437 Lenti-HCMV pp65 T cell receptor (TCRCD8-CMV#1) Viral Particle
TCR-L148 Human anti-CMV pp65 T cell receptor (TCRCD4-CMV#1), pCDTCR1
TCR-L140 Human anti-CMV pp65 T cell receptor (TCRCD8-CMV#8), pCDTCR1
TCR-L094 Human anti-pp65 (NLVPMVATV) T Cell Receptor, pMP71
TCR-L141 Human anti-CMV pp65 T cell receptor (TCRCD8-CMV#9), pCDTCR1
TCR-L100Z Human anti-pp65 (aa265-275) T cell receptor (Codon optimized and cysteine modified), pCDTCR1
VP-TCR-C439 Lenti-HCMV pp65 T cell receptor (TCRCD8-CMV#8) Viral Particle
TCR-L098 Human anti-pp65 (KYQEFFWDANDIYRI) T Cell Receptor, pLZRS
VP-TCR-C436 Lenti-pp65 T cell receptor (Codon optimized and cysteine modified) Viral Particle
TCR-L142 Human anti-CMV pp65 T cell receptor (TCRCD8-CMV#10), pCDTCR1
VP-TCR-C427 Lenti-pp65 T cell receptor (12) Viral Particle
VP-TCR-C444 Lenti-HCMV pp65 T cell receptor (TCRCD8-CMV#14) Viral Particle
TCR-C215Z Human anti-pp65 T cell receptor (JG-33), pCDTCR1
VP-TCR-C445 Lenti-HCMV pp65 T cell receptor (TCRCD8-CMV#15) Viral Particle
VP-TCR-C435 Lenti-pp65 (TPRVTGGAM) T cell receptor (Codon optimized and cysteine modified) Viral Particle
TCR-C219Z Human anti-pp65 T cell receptor (C7), pCDTCR1
TCR-L099Z Human anti-pp65 (aa417-426) T cell receptor (Codon optimized and cysteine modified), pCDTCR1
VP-TCR-C438 Lenti-HCMV pp65 T cell receptor (TCRCD8-CMV#4) Viral Particle
TCR-L150 Human anti-CMV pp65 T cell receptor (TCRCD4-CMV#5), pCDTCR1
TCR-L097Z Human anti-pp65 (aa509-523) T cell receptor (Codon optimized), pCDTCR1

OthersViral Infection

Online Inquiry

Name:
Phone:
*E-mail Address:
*Service & Products Interested:
Project Description:
*Verification Code:
Please input "biolabs"(case insensitive) as verification code.
CB Promise
CONTACT US
45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-871-5806
Europe: 44-207-048-3343
Fax: 1-631-207-8356
Email:
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-048-3343

Distributors

To view the contact information for a specific location, select the desired country:

Australia
australia

FOLLOW US ON