Anti-EBNA3 T cell receptor (LC13), pCDTCR1(TCR-C047Z)

The vector of anti-EBNA3 T cell receptor (TCR) is constructed for the engineering of T cell to target EBV EBNA3. The T cells are genetically modified through transduction with a lentiviral vector expressing EBNA3-specific T cell receptor. And the vector product was designed for the treatment of EBV infection.


Details


Target
EBNA3
Target Species
EBV
Epitope
FLRGRAYGL
Format
Non-modified
HLA
HLA-B*0801
Targeting Diseases
EBV infection
Vector Name
pCDTCR1
Vector Length
~8kb
Vector Type
Lentiviral
Antibody Clone
LC13
Antibody Host
Human

Target


Gene Name
Epstein-Barr nuclear antigen 3
Official Symbol
EBNA3
UniProt ID
Synonyms
EBNA3; Epstein-Barr nuclear antigen 3
Introduction
Plays an essential role for activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA3A probably contributes to a negative autoregulatory control loop.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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CONTACT US

USA
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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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Tel: 44-207-097-1828

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