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Anti-EBNA3C T cell receptor (DM1), pCDTCR1 (TCR-C055Z)

The vector of anti-EBNA3C T cell receptor (TCR) is constructed for the engineering of T cell to target EBV EBNA3C. The T cells are genetically modified through transduction with a lentiviral vector expressing EBNA3C-specific T cell receptor. And the vector product was designed for the treatment of EBV infection.

Details

  • Target
  • EBNA3C
  • Target Species
  • EBV
  • Epitope
  • ENLLDFVRF
  • Format
  • Non-modified
  • HLA
  • HLA-B*4405
  • Targeting Diseases
  • EBV infection
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral
  • Antibody Clone
  • DM1
  • Antibody Host
  • Human

Target

  • Gene Name
  • Epstein-Barr nuclear antigen 3C
  • Official Symbol
  • EBNA3C
  • Synonyms
  • EBNA3C; Epstein-Barr nuclear antigen 3C; EBNA6; EBV nuclear antigen 6
  • Introduction
  • Plays an essential role for the activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA6 probably contributes to a negative autoregulatory control loop. Alternatively, EBNA6 also regulates the transcription of the EBV oncogene LMP1 in a cell cycle-dependent manner. Modulates the activity of several host proteins involved in cell cycle regulation including host cyclin A, MYC, RB, p21 and p27 mainly through binding to the host SCF(SKP2) complex. Inhibits the promoter of host H2AX and targets H2AX to proteasomal degradation in order to promote latency and cell proliferation.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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