Anti-MAGE-A12 T cell receptor (FM8), pCDTCR1(TCR-C118Z)

The vector of anti-MAGE-A12 T cell receptor (TCR) is constructed for the engineering of T cell to target Human MAGE-A12. The T cells are genetically modified through transduction with a lentiviral vector expressing MAGE-A12-specific T cell receptor. And the vector product was designed for the treatment of Melanoma.


Details


Target
MAGE-A12
Target Species
Human
Epitope
aa 170-178
Format
Non-modified
HLA
HLA-C*07
Targeting Diseases
Melanoma
Vector Name
pCDTCR1
Vector Length
~8kb
Vector Type
Lentiviral
Antibody Clone
FM8
Antibody Host
Human

Target


Gene Name
MAGE family member A12
Official Symbol
MAGEA12
Gene ID
UniProt ID
Synonyms
MAGEA3; Cancer/Testis Antigen Family 1, Member 3; Cancer/Testis Antigen Family 1; MAGE3; MAGEA6; Antigen MZ2-D; Melanoma-Associated Antigen 3; Melanoma Antigen Family A, 3; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Melanoma
Introduction
This gene is closely related to several other genes clustered on chromosome X. These genes may be overexpressed in tumors. Multiple alternatively spliced variants encoding the same protein have been identified.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Carcinoma

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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