Anti-TARP T cell receptor, pCDTCR1(TCR-C242Z)

The vector of anti-TARP T cell receptor (TCR) is constructed for the engineering of T cell to target Human TARP. The T cells are genetically modified through transduction with a lentiviral vector expressing TARP-specific T cell receptor. And the vector product was designed for the treatment of Prostate and breast cancer.


Details


Target
TARP
Target Species
Human
Epitope
FPPSPLFFFL
Format
Non-modified
HLA
HLA-A2
Targeting Diseases
Prostate and breast cancer
Vector Name
pCDTCR1
Vector Length
~8kb
Vector Type
Lentiviral
Antibody Host
Human

Target


Gene Name
TCR gamma alternate reading frame protein
Official Symbol
TARP
Gene ID
UniProt ID
Synonyms
CD3G; TCRG; TCRGV; TCRGC1; TCRGC2; TARP
Introduction
In some non-lymphoid tissues, the unrearranged T cell receptor gamma (TRG@) locus is expressed. The resulting transcript contains a subset of the TRG@ gene segments and is shorter than TRG@ transcripts expressed in lymphoid tissues. This RefSeq record represents the unrearranged TRG@ locus transcript; the complete TRG@ locus is represented by the genomic RefSeq NG_001336. The transcript represented by this RefSeq has two open reading frames (ORFs) that encode different proteins. The downstream ORF is in the same frame as TRG@ and its protein product is similar to TRG@ proteins. The upstream ORF uses a different reading frame and encodes a novel protein.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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