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Anti-UL40 T cell receptor (KK50.4), pCDTCR1 (TCR-C255Z)

The vector of anti-UL40 T cell receptor (TCR) is constructed for the engineering of T cell to target CMV UL40. The T cells are genetically modified through transduction with a lentiviral vector expressing UL40-specific T cell receptor. And the vector product was designed for the treatment of Cytomegalovirus infection.

Details

  • Target
  • UL40
  • Target Species
  • CMV
  • Epitope
  • VMAPRTLIL
  • Format
  • Non-modified
  • HLA
  • HLA-E*0103
  • Targeting Diseases
  • Cytomegalovirus infection
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral
  • Antibody Clone
  • KK50.4
  • Antibody Host
  • Human

Target

  • Gene Name
  • Protein UL40
  • Official Symbol
  • UL40
  • Synonyms
  • UL40; Protein UL40
  • Introduction
  • Plays a role in the protection against host NK-cell cytotoxicity by upregulating the cell surface expression of HLA-E independent of TAP (HLA-E has an inhibitory effect on the cytotoxic activity of the NK cell). Promotes also cell surface expression of UL18, another viral protein involved in NK-cell evasion.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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