pCDCAR1 Integrin αvβ6 h(ζ)(CAR-MZ229)

The vector of Bpep based chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human Integrin αvβ6. The T cells are genetically modified through transduction with a lentiviral vector expressing Bpep peptide linked to CD3ζ signaling domains. And the vector product was designed for the treatment of human ovarian cancer.


Details


Target
Alpha(v) beta(6) integrin (αvβ6)
Target Species
Human
Targeting Cell Type
T cell
Targeting Diseases
Human ovarian cancer
Generation
First
Vector Name
pCDCAR1
Vector Length
~8kb
Vector Type
Lentiviral
Receptor Construction
Bpep-CD4TM-CD3ζ
Discription of Signaling Cassetes
CD3ζ
CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.

Target


Gene Name
integrin subunit alpha V
Official Symbol
ITGAV
Gene ID
Synonyms
CD51; MSK8; VNRA; VTNR

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-048-3343

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