The vector of anti-La protein chimeric antigen receptor (CAR) is universal CAR constructed for the engineering of T cell to target La epitope. The T cells are genetically modified through transduction with a retroviral vector expressing scFv of anti-La protein antibody linked to CD28 and CD3ζ signaling domains. And the vector product was designed for the treatment of various cancers of which the cancer cells are recognized with La epitope-fused antibody.
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