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Lenti-FRα (Folate receptor-alpha) CAR (scFv-BBζ, MOv19)-VP (VP-CAR-LC850)

The ready-to-use lentiviral particles of Lenti-FRα (Folate receptor-alpha)(Folate receptor-alpha) CAR (scFv-BBζ, MOv19)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (MOv19)-CD137-CD3ζ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.

Specifications

  • Type of Therapeutics
  • Chimeric Antigen Receptor
  • Target
  • FRα (Folate receptor-alpha)
  • Expression Cassette
  • scFv (MOv19)-CD137-CD3ζ
  • Clone
  • MOv19
  • Promotor
  • EF1a
  • Packaging System
  • Lentivirus
  • Packaging Cell
  • 293T
  • Targeting Diseases
  • FRα (Folate receptor-alpha)positive human cancers

Target

  • Introduction
  • The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.
  • Alternative Names
  • FBP; FOLR

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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