Lenti-La protein (E5B9) CAR (scFv-28ζ)-VP(VP-CAR-LC527)

The ready-to-use lentiviral particles of Lenti-La protein (E5B9) CAR (scFv-28ζ)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv-CD28-CD3ζ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.


Specifications


Type of Therapeutics
Chimeric Antigen Receptor
Target
La protein (E5B9)
Expression Cassette
scFv-CD28-CD3ζ
Promotor
CMV
Packaging System
Lentivirus
Packaging Cell
293T
Targeting Diseases
Various cancer cells stained with 5B9 epitope-fused antibodies

Target


Introduction
The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein.
Alternative Names
SSB; Sjogren syndrome antigen B; La; LARP3; La/SSB
Gene ID

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-048-3343

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