Lenti-survivin TCR-VP(VP-TCR-C017)

The ready-to-use lentiviral particles of Lenti-survivin TCR-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of Murinized (from Human) TCR will be driven by a CMV promotor. The target gene of TCR packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.


Specifications


Type of Therapeutics
T cell receptor
Target
survivin
Promotor
CMV
Packaging System
Lentivirus
Packaging Cell
293T
Targeting Diseases
Diseases involving malignant cells expressing survivin

Target


Introduction
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Alternative Names
SSX; HD21; CT5.2; CT5.2A; HOM-MEL-40; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Synovial sarcoma
Gene ID

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Tel: 1-631-381-2994
Fax: 1-631-207-8356
Email:

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