Anti-FTO T cell receptor (2C), pCDTCR1(TCR-C009Z)
The vector of anti-FTO T cell receptor (TCR) is constructed for the engineering of T cell to target Human FTO. The T cells are genetically modified through transduction with a lentiviral vector expressing FTO-specific T cell receptor.
FTO, alpha-ketoglutarate dependent dioxygenase
FTO; GDFD; ALKBH9; BMIQ14; alpha-ketoglutarate dependent dioxygenase
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.