All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
Creative Biolabs establishes physiologically relevant models to screen and optimize CAR-T cells through the organ-on-a-chip platform. These models will provide valuable information to better understand the CAR-T cell therapies in controlled microenvironments.
Screening CAR-T cells is important for developing safe, effective, and personalized therapies. It allows for the evaluation of potential side effects or adverse reactions of CAR-T cell therapy. Screening helps determine the effectiveness of CAR-T cells in targeting and killing target cells. It also helps tailor CAR-T cell therapy, considering factors such as tumor type, genetic profile, and immune response. The screening process of CAR-T cells requires strict control to ensure the accuracy and effectiveness of CAR design and transfection.
Organ-on-a-chip is a small functional unit able to simulate the level of the organ in vitro. CellRapeutics™ organ-on-a-chip platform allows researchers to observe how the CAR-T cells interact with the surrounding cells and tissues, assess their cytotoxicity, and evaluate their efficacy in a controlled microenvironment.
Organ-on-a-chip devices allow researchers to control key parameters such as cell types, cell-cell interactions, and chemical gradients, enabling precise manipulation of the T-cell environment. Additionally, researchers can reduce the reliance on animal models for T-cell screening by using the organ-on-a-chip platform.
Fig.1 Advantages of organ-on-a-chip technology compared to cell culture and animal models.1
Screening CAR-T cells through the organ-on-a-chip platform typically involves the following points:
Based on our advanced CellRapeutics™ Organ-on-a-chip platform for CAR T-cell screening, Creative Biolabs is dedicated to providing CAR-T cell screening service to accelerate the screening process and increase efficiency. For more information, please don't hesitate to contact us.
References
For any technical issues or product/service related questions, please leave your information below. Our team will contact you soon.
The latest newsletter to introduce the latest breaking information, our site updates, field and other scientific news, important events, and insights from industry leaders
LEARN MORE NEWSLETTERCellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
LEARN MORE SOLUTIONSilence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
LEARN MORE NOVEL TECHNOLOGYCanine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
LEARN MORE SOLUTION