The vector of anti-ErbB2 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human ErbB2. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-ErbB2 antibody linked to a CD8 hinge-transmembrane domain and CD3-zeta signaling domains. And the vector product was designed as a medicament, in particular in the treatment of cancer and in adoptive, target-cell specific immunotherapy.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
|OAdCmodV-YX0979||Oncolytic Adenovirus (Capsid modified Ad5, pCMV-Δ55k, Anti-ERBB2-2), Viral particle|
|TCR-L225||Human anti-Her2 T cell receptor (D1), pCDTCR1|
|OAdCmodV-YX1021||Oncolytic Adenovirus (Capsid modified Ad5, phTERT-Δ19k, Anti-ERBB2-2), Viral particle|
|VP-TCR-C138||Lenti-Her2 T cell receptor (H3) Viral Particle|
|VP-CAR-LC221||Lenti-ErbB2 CAR (scFv-CD28, OTI5C4) Viral Particle|
|CAR-NK-2-M331-BZ||Anti-ErbB2 scFv h(41BB-CD3ζ) CARNK, pCDCAR1|
|VP-TCR-C135||Lenti-Her2 T cell receptor (E2) Viral Particle|
|OAdCmodV-YX1017||Oncolytic Adenovirus (Capsid modified Ad5, phTERT-Δ24/55k, Anti-ERBB2-4), Viral particle|
|OAdCmodV-YX1018||Oncolytic Adenovirus (Capsid modified Ad5, phTERT-Δ24/55k, Anti-ERBB2-5), Viral particle|
|OAdCmodV-YX1014||Oncolytic Adenovirus (Capsid modified Ad5, phTERT-Δ24/55k, Anti-ERBB2-1), Viral particle|
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