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pCDCAR1 FITC h(28), T (CAR-T-1-L340-2)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-FITC chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human FITC. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-FITC antibody linked to CD28 signaling domains. And the vector product was designed for targeting and killing tumors via tumor-associated antigens.

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Details

  • Target
  • FITC
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • FR+ cancer
  • Generation
  • First
  • Vector Name
  • pCDCAR1
  • Vector Length
  • 8kb
  • Vector Type
  • Lentiviral
  • Receptor Construction
  • scFv-CD28
  • Discription of Signaling Cassetes
  • CD28
    CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatorysignals required for T cell activation and survival. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins which are expressed on antigen-presenting cells(APC). CD28 modulates the primary TCR/CD3ζ signal in a different fashion than the late costimulatory elements OX40 and 4-1BB. CD28 enhances the expression of downstream regulators that impact on T-cell proliferation, death, differentiation, and effector functions. CAR+ T cells containing the CD28 endodomain showed strikingly enhanced sustained T cell activation, growth, survival. And CD28 results in a brightly expressed, stable receptor as the transmembrane domain. Including CD28 costimulatory domains in CARs led to enhanced anti-malignancy efficacy.

Target

  • Clone
  • 4-4-20
  • Host
  • Mouse
  • Target Species
  • Human
  • Gene Name
  • Fluorescein Isothiocyanate
  • Synonyms
  • FITC; FI; Fluorescein Isothyocianate; Fluorescyl Antibody

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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