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pCDCAR1 FITC h(FcεRIγ), T (CAR-T-1-L340-G)

The vector of anti-FITC chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human FITC. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-FITC antibody linked to FcεRIγ signaling domains. And the vector product was designed for targeting and killing tumors via tumor-associated antigens.

Details

  • Target
  • FITC
  • Target Species
  • Human
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • FR+ cancer
  • Generation
  • First
  • Vector Name
  • pCDCAR1
  • Vector Length
  • 8kb
  • Vector Type
  • Lentiviral
  • Receptor Construction
  • scFv-FcεRIγ
  • Discription of Signaling Cassetes
  • FcεRIγ
    The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high-affinity receptor for the Fc region of immunoglobulin E (IgE). FcεRI is a key molecule involved in allergic reactions. It is a tetramer composed of 1alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. The scFv-based CARs engineered to contain a signaling domain from FcεRIγ have been shown to deliver a potent signal for T cell activation and function.
  • Antibody Clone
  • 4-4-20
  • Antibody Host
  • Mouse

Target

  • Gene Name
  • fluorescein isothiocyanate
  • Official Symbol
  • FITC
  • Synonyms
  • FITC; FI; fluorescein isothyocianate; fluorescyl antibody; CD28; Chimeric antigen receptor; T cell;
    Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen
    receptors; scFv

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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