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pCDCAR1 FKBP5 h(8ζ), T (CAR-T-2-L409-8Z)

The vector of anti-FKBP5 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human FKBP5. The T cells are genetically modified through transduction with a lentiviral vector expressing FKBP linked to a CD8 hinge-transmembrane domain and CD3-zeta signaling domains. And the vector product was designed for the treatment of leukemia.

Details

  • Target
  • FKBP5
  • Target Species
  • Human
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • Leukemia
  • Generation
  • Second
  • Vector Name
  • pCDCAR1
  • Vector Length
  • 8kb
  • Vector Type
  • Lentiviral
  • Receptor Construction
  • scFv-CD8-CD3ζ
  • Discription of Signaling Cassetes
  • CD8 CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T cell receptor(TCR). Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the class I MHC protein. This affinity between CD8 and MHC molecule keeps the chimeric T cell receptor and the target cell bound closely together during antigen-specific activation.
    CD3ζ
    CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta,which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.
  • Antibody Host
  • Human

Target

  • Gene Name
  • FK506 Binding Protein 5
  • Official Symbol
  • FKBP5
  • Gene ID
  • 2289
  • Synonyms
  • FK506 Binding Protein 5; 54 KDa Progesterone Receptor-Associated Immunophilin; 51 KDa FK506-Binding Protein; Androgen-Regulated Protein 6; HSP90-Binding Immunophilin; FK506-Binding Protein 5; PPIase FKBP5; 51 KDa FKBP; FF1 Antigen; EC 5.2.1.8; Rotamase; FKBP-51;

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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