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EXPLORE MORECreative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsTo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
EXPLORE MORE HighlightsAll products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
CAR CD3-X Bispecific Antibody
Fig.1 The structure of CD3-X bispecific antibody. (Wikipedia)
As an artificial bispecific monoclonal antibody, CD3-X Bispecific Antibodies have been extensively studied as anticancer drugs. CD3-X Bispecific Antibody affects the cytotoxicity of host T cells, thereby exerting anticancer effects. Creative Biolabs offers a variety of CAR CD3-X Bispecific Antibody products to help you accelerate oncology research.
Custom CAR CD3-X Bispecific Antibody
Like other bispecific antibodies, CAR CD3-X Bispecific Antibody primarily redirects T cells to specific tumor antigens and directly activates T cells to function. Creative Biolabs offers custom CAR CD3-X Bispecific Antibodies, which typically target both tumor antigens and CD3 molecules. This CD3-X Bispecific Antibody non-covalently binds CD3 molecules to T cell receptors (TCRs) and participates in antigen-specific signal transduction to induce T cell activation.
Fig.2 CD3-X bispecific antibody-mediated mechanism of tumor cell lysis.1
Applications of CAR CD3-X Bispecific Antibody
Several CD3-X bispecific antibodies have been used in clinical trials, and the following are some examples related to them in published paper.
Fig.3 Comparison of blinatumomab and chemotherapy for relapsed or refractory acute lymphoblastic leukemia.2
Fig.4 CAR T cell copy/mcg DNA after glofitamab treatment.3
Fig.5 Efficacy of non-hodgkin lymphomas patients with continuous infusion of blinatumomab in an incremental dosing regimen.4
As a leading global provider of CAR products and services, Creative Biolabs offers a broad range of CAR CD3-X Bispecific Antibody products to meet your research needs. If you have any questions or product and service requirements in the CAR field, please contact us immediately. We will have professional scientists in the CAR field to solve your problems and provide professional advice!
You can find more supplementary products in our CAR Complementary section, please click to find out!
References
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NEW SOLUTION
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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