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EXPLORE MORECreative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsTo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
EXPLORE MORE HighlightsAll products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
TCR-NK Therapy
Natural killer (NK) cell therapy is a promising cancer therapeutic approach due to its cytotoxic capacity. Therefore, NK cells can be adapted into a tool to fight cancer. NK cells engineered with TCR expression (TCR-NK cells) is a therapeutic strategy that combines the intrinsic antitumor effector functions of NK cells with cancer-specific targeting of TCRs. NK-TCR cell enhances their therapeutic activity and tumor-targeting capability through additional TCR-mediated lysis than native NK cells. Differing from TCR-T cells, TCR-NK cells have superiority in overcoming the difficulties of TCR mismatching. TCR-NK cells will be a unique cellular therapeutic strategy that provides patients with greater hope for relief.
Fig.1 The process of TCR-NK cell generation.1
TCR-NK Cell Products
Creative Biolabs is dedicated to developing pioneering TCR-NK cell products that combine the advantages of TCRs with those of NK cells, addressing the challenges of treating solid tumors. We provide one-stop TCR-NK development services, including TCR selection, design, construction, and analysis. Our TCR-NK cell development platform allows us to effectively transfer the TCR α/β chain along with the CD3 signaling complex into NK cells. We also provide analysis assays to characterize that the TCR-NK cells are able to express a functional TCR. In addition, a series of functional assays and in vivo efficacy assays to validate these cells.
References
Associated Antigen Target
NEWSLETTER
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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NEW SOLUTION
Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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