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AKTIP

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The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-CN075 Anti-AKTIP (2B2) h(CD28-CD3ζ) CAR, pCDCAR1 Human 2B2 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CN076 Anti-AKTIP (6G8) h(CD28-CD3ζ) CAR, pCDCAR1 Human 6G8 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CN176 Anti-AKTIP (2B2) h(41BB-CD3ζ) CAR, pCDCAR1 Human 2B2 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CN177 Anti-AKTIP (6G8) h(41BB-CD3ζ) CAR, pCDCAR1 Human 6G8 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0020 Anti-AKTIP (CBXF-0099) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXF-0099 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0021 Anti-AKTIP (CBXF-2730) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXF-2730 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ3444 Anti-AKTIP (CBXF-0099) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXF-0099 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ3445 Anti-AKTIP (CBXF-2730) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXF-2730 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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