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CD274

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and nonhematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin Vlike and Clike domains. Interaction of this ligand with its receptor inhibits Tcell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic Tcell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.
  • CAR Vector Products

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    CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
    XS-1222-ZP1377 CD274 (PDCD1 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human CD274-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
    XS-1222-ZP2777 CD274 (PDCD1 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human CD274-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
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